RAD-140 (Testolone) Protocol Guide
RAD-140 (Testolone) is a non-steroidal selective androgen receptor modulator (SARM) developed by Radius Health for potential treatment of breast cancer and muscle wasting. It selectively binds androgen receptors in muscle and bone with an anabolic-to-androgenic ratio of approximately 90:1, meaning potent anabolic effects with reduced prostate and hair follicle androgenic activity. RAD-140 also demonstrates neuroprotective properties via AR-dependent pathways. This protocol covers 10-20mg daily oral dosing for 8-12 weeks, mandatory PCT, liver and hormonal monitoring, and harm reduction strategies.
Protocol Overview
- Compound
- RAD-140 (Testolone)
- Category
- Non-Steroidal SARM
- Mechanism
- Selective androgen receptor agonist in muscle/bone; tissue-selective activation; AR-mediated neuroprotection; partial agonist in prostate
- MW
- 393.8 Da
- Half-Life
- ~60 hours
- Form
- Oral solution or capsule
- Route
- Oral
- Frequency
- Once daily
- Cycle
- 8-12 weeks + 4-week PCT
Dosing
| Phase | Weeks | Dose | Notes |
|---|---|---|---|
| Introduction | 1-2 | 10 mg/day | Assess tolerance; take with food AM |
| Standard | 3-8 | 15-20 mg/day | Once daily, same time each day |
| Extended (advanced) | 9-12 | 10-20 mg/day | Only if bloods remain acceptable |
| PCT | Post-cycle 1-4 | Enclomiphene 12.5-25mg or Nolvadex 20/10mg | Begin 3-5 days after last dose |
Do not exceed 12 weeks. The long half-life (~60 hours) means steady-state is reached within ~2 weeks. Liver support (NAC 600mg + TUDCA 250mg daily) is recommended throughout the cycle.
Timeline
Side Effects & Stacking
Side Effects
- Testosterone suppression (dose and duration dependent)
- Elevated liver enzymes (ALT/AST) — monitor closely
- HDL cholesterol reduction (lipid impact)
- Mild aggression/irritability
- Hair shedding (rare, usually reversible)
- Mild insomnia at higher doses
- Lethargy toward end of cycle (suppression sign)
Stacking
- MK-677: GH axis support + appetite (popular combination)
- GW-501516 (Cardarine): Endurance + fat oxidation (research only)
- BPC-157: Joint/tendon support during heavy training
- NAC + TUDCA: Liver protection (essential, not optional)
- Do NOT stack with: other SARMs, oral steroids, or prohormones
Blood Work
| Panel | Markers | Timing |
|---|---|---|
| Hormonal | Total/free testosterone, LH, FSH, SHBG, estradiol | Baseline, Week 6, post-PCT Week 4 |
| Liver | ALT, AST, GGT, bilirubin | Baseline, Week 4, Week 8 |
| Lipids | Total cholesterol, HDL, LDL, triglycerides | Baseline, Week 8 |
| Basic | CBC, CMP, PSA (males over 40) | Baseline, Week 8 |
Critical: If ALT/AST exceed 3x upper limit of normal, discontinue immediately. If total testosterone drops below 200 ng/dL mid-cycle with significant symptoms, consider early cycle termination and PCT. Post-PCT blood work is mandatory to confirm HPTA recovery.
