Launching Q3 2026
The Path to Peptides Podcast
Evidence-based peptide education · 20 episodes in production
The Path to Peptides Podcast will deliver evidence-based peptide research across 20 episodes covering GLP-1 agonists, BPC-157, TB-500, peptide stacking, reconstitution protocols, regulation, nootropic peptides, anti-aging compounds, and more. Episodes will average 44 minutes and cite primary literature. Episode scripts and outlines are complete. Audio production begins Q3 2026.
RFK, Testosterone & the Future of Peptide Regulation
An examination of the shifting regulatory landscape under RFK Jr.'s HHS leadership and what it means for peptide research access in 2026. We analyze proposed FDA guidance changes affecting compounded peptides, discuss testosterone reclassification debates, and explore how researchers can navigate the evolving legal framework with confidence.
A comprehensive breakdown of retatrutide's triple GLP-1/GIP/glucagon receptor agonist mechanism. We review phase 2 trial data showing unprecedented weight reduction outcomes, discuss pharmacokinetics, and analyze how triple agonism compares to tirzepatide and semaglutide in head-to-head data.
Key Topics
- Triple receptor agonism: GLP-1, GIP, glucagon mechanisms explained
- Phase 2 trial data: weight loss percentages and side effect profile
- Pharmacokinetic comparison with tirzepatide and semaglutide
- Dosing titration schedule and patient selection considerations
A head-to-head comparison of the three leading GLP-1 class compounds. We break down clinical trial efficacy data, side effect profiles, mechanism differences, cost considerations, and practical guidance for researchers evaluating each compound in 2026.
Key Topics
- STEP vs SURPASS vs Phase 2 retatrutide efficacy comparisons
- Nausea, vomiting, and GI side effect mitigation strategies
- Mechanism differences: single vs dual vs triple agonism
- Cost, availability, and compounding pharmacy landscape
Deep dive into the classic tissue repair stack combining BPC-157 and TB-500. We examine the published research on their complementary mechanisms, discuss optimal dosing ratios and timing, and review the evidence base for synergistic effects on tendon, ligament, and muscle repair.
Key Topics
- BPC-157 cytoprotection and angiogenesis pathway mechanisms
- TB-500 actin-binding and cell migration roles
- Stack ratios, timing windows, and injection site strategy
- Injury-specific protocol modifications from the literature
Examining the science behind oral peptide bioavailability and the innovations making non-injectable administration viable. We review permeation enhancer technology, protease resistance strategies, and which peptides are currently in oral formulation development pipelines.
Key Topics
- Why oral bioavailability is the central challenge for peptide delivery
- Permeation enhancers and intestinal absorption mechanisms
- Semaglutide oral (Rybelsus) as a case study in formulation
- Pipeline compounds targeting oral delivery in 2026
A systematic ranking and comparison of the top growth hormone secretagogues in the research literature. We evaluate each compound on mechanism, published efficacy data, half-life, cost, and practical protocol considerations for body composition research.
Key Topics
- GHRH vs ghrelin mimetic mechanisms and their synergistic interaction
- CJC-1295 DAC vs no-DAC: which is appropriate for which protocol
- MK-677 oral bioavailability and IGF-1 elevation data
- Tesamorelin clinical trial data and FDA-approved indications
Exploring the neuroscience behind cognitive-enhancing peptides. We review Semax's BDNF-modulating effects, Selank's anxiolytic mechanisms and its relationship to tuftsin, and Dihexa's potent HGF/c-Met activity with implications for neuroregeneration research.
Key Topics
- Semax ACTH analog mechanism and BDNF upregulation in rat models
- Selank anxiolytic effects and GABA-A modulation research
- Dihexa's remarkable potency compared to BDNF in neural repair studies
- Intranasal vs subcutaneous administration for nootropic peptides
A comprehensive guide to the biomarkers researchers should track when studying peptide effects. We cover baseline panels, hormone markers, metabolic indicators, and how to interpret out-of-range results in the context of specific research protocols.
Key Topics
- Baseline panel: CMP, CBC, lipids, and thyroid markers
- Hormone panel: total/free testosterone, SHBG, estradiol, IGF-1
- GLP-1 protocol monitoring: HbA1c, amylase, lipase flags
- Interpreting results and when to pause a research protocol
A systematic framework for evaluating peptide combinations. We examine mechanistic synergies, potential receptor conflicts, timing considerations, and the published research supporting or cautioning against common multi-peptide protocols.
Key Topics
- Framework for evaluating whether two peptides are synergistic or redundant
- Receptor competition and desensitization risks in stacks
- Timing: simultaneous vs offset dosing for different compound classes
- The 3 most evidence-supported stacks and 3 to avoid
Exploring the cutting edge of longevity peptide research. We review Epithalon's telomerase-activating effects, the senolytic mechanism of FOXO4-DRI in clearing senescent cells, and how NAD+ precursor strategies intersect with peptide-based anti-aging protocols.
Key Topics
- Epithalon telomere elongation: what the Khavinson research actually shows
- FOXO4-DRI senolytic mechanism and mouse lifespan extension data
- NAD+ and its relationship to sirtuin and PARP activity
- Evidence grades for each compound and realistic expectations
An in-depth look at immune-modulating peptides and their mechanisms. We cover Thymosin Alpha-1's T-cell activation properties, LL-37's dual antimicrobial and immunomodulatory roles, and KPV's anti-inflammatory pathway via the melanocortin receptor system.
Key Topics
- Thymosin Alpha-1 clinical applications and FDA orphan drug status
- LL-37 cathelicidin: antimicrobial peptide with immunomodulatory duality
- KPV tripeptide and MC1R pathway anti-inflammatory signaling
- When immune peptides are appropriate vs contraindicated in protocols
Addressing the gap in gender-specific peptide research. We review how hormonal cycles affect peptide pharmacokinetics, discuss dosing adjustments supported by the literature, and explore which compounds have particular relevance or risk for female physiology.
Key Topics
- How estrogen and progesterone cycles affect peptide receptor sensitivity
- GLP-1 dosing in female vs male subjects: published comparison data
- PT-141 and melanocortin research specific to female populations
- Protocols to avoid and red flags during cycle phases
A practical guide to peptide quality verification. We walk through HPLC purity testing, mass spectrometry identity confirmation, what certificates of analysis should contain, how to read CoAs correctly, and how to evaluate suppliers based on their testing transparency.
Key Topics
- HPLC purity: what percentage to accept and what red flags look like
- Mass spectrometry and how to confirm peptide identity from a CoA
- Endotoxin testing: why LAL assay results matter for injectable research
- Checklist: 7 things every CoA should include
The definitive guide to peptide reconstitution, our most-listened episode. We cover bacteriostatic water ratios, dilution calculations for different vial sizes, sterile technique, storage temperature requirements, light sensitivity, and how to calculate accurate per-unit doses.
Key Topics
- Bacteriostatic vs sterile water: when each is appropriate
- Step-by-step dilution math for 2mg, 5mg, and 10mg vials
- Refrigerator vs freezer storage and freeze-thaw cycle limits
- Use the Reconstitution Calculator for real-time dose math
Exploring the evidence base for copper peptides and other topical research peptides. We review GHK-Cu's collagen-stimulating and wound-healing properties, discuss the research on Argireline and Leuphasyl, and evaluate the quality of available cosmetic peptide studies against pharmaceutical-grade research standards.
Key Topics
- GHK-Cu collagen synthesis and anti-inflammatory mechanisms
- Argireline's botulinum toxin-adjacent mechanism at neuromuscular junctions
- Penetration limitations of topical peptides and liposome delivery
- Separating marketing claims from peer-reviewed evidence in cosmeceuticals
A balanced, evidence-based review of selective androgen receptor modulators. We examine the clinical trial landscape, discuss tissue selectivity mechanisms, review documented side effects including lipid panel changes and LH suppression, and place SARMs in context relative to traditional peptide protocols.
Key Topics
- How tissue selectivity is achieved and why it remains imperfect
- LGD-4033, RAD-140, and MK-2866: clinical trial data compared
- Testosterone suppression: how much, how fast, how to monitor
- FDA enforcement landscape and the legal status question in 2026
A comprehensive breakdown of the current regulatory status of research peptides in the US, EU, Australia, and Canada. We cover FDA scheduling, the 503A/503B compounding pharmacy framework, and practical guidance for researchers navigating compliance in a shifting landscape.
Key Topics
- FDA's "bulk drug substance" nomination process and its current status
- 503A vs 503B compounding pharmacies: what researchers need to know
- Country-by-country status: US, UK, Canada, Australia, EU
- Research-use-only labeling: what it means legally
A deep dive into Path to Peptides' evidence grading methodology. We explain how we evaluate study quality, the difference between animal model and human clinical data, and how the A–D rating system helps researchers quickly assess the strength of evidence for any compound in our database.
Key Topics
- Why animal model data alone earns a D rating by default
- What separates a B from an A: RCTs, sample size, replication
- How to read a compound protocol card and use the evidence grade
- The 174-compound database and how grades are assigned and reviewed
The complete beginner's guide to starting peptide research. We cover how to select a starting compound based on your research goals, sourcing and quality considerations, reconstitution basics, tracking methodology, and the safety checklist every first-time researcher should complete.
Key Topics
- Compound selection framework: matching goals to evidence-grade compounds
- Sourcing checklist: what to verify before purchasing from any supplier
- Setting up a research log and what data points to track
- The 5 safety rules that apply to every first protocol
Our inaugural episode covers the fundamentals of peptide science. We explain what peptides are at the molecular level, how they differ from proteins and small molecules, why receptor specificity matters for safety and efficacy, and what distinguishes evidence-based peptide research from unsubstantiated claims.
Key Topics
- Peptide definition: amino acid chains, molecular weight, and the protein boundary
- How peptides bind receptors and why specificity is everything
- Endogenous vs synthetic peptides and the research landscape
- The hype problem: how to identify unsupported claims in peptide content
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20 episodes are scripted and ready for production. Be the first to listen when we go live in Q3 2026.
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About the Podcast
The Path to Peptides podcast will break down complex peptide research into clear, actionable insights. Each episode will cover mechanisms of action, clinical evidence grades, dosing considerations from the literature, and practical research applications. Episodes will cite primary sources and use Path to Peptides' A-D evidence grading system. Our goal is to make the primary literature accessible to researchers at every level -- without hype, without commercial bias, and without shortcuts. Episode scripts and outlines are complete. Audio production begins Q3 2026.
Frequently Asked Questions
What topics does the podcast cover?
The Path to Peptides Podcast covers evidence-based peptide research across 20 episodes. Topics include GLP-1 agonists (semaglutide, tirzepatide, retatrutide), recovery peptides (BPC-157, TB-500), growth hormone secretagogues, peptide stacking protocols, reconstitution techniques, FDA regulation and legal status, nootropic peptides, anti-aging compounds, and emerging research. Each episode cites primary literature and averages 44 minutes of in-depth analysis.
When will episodes be available?
Audio production begins Q3 2026. All 20 episode scripts and outlines are complete. Once production begins, new episodes will be released weekly on Mondays. Subscribe for a launch notification to be the first to listen.
Where will I be able to listen?
The podcast will be available free on all major platforms including Spotify, Apple Podcasts, YouTube, and more once production is complete. No subscription, account, or payment will be required. Enter your email above to get notified at launch.
