KPV Protocol Guide
KPV is a tripeptide fragment derived from alpha-melanocyte stimulating hormone (alpha-MSH). It retains the potent anti-inflammatory properties of the parent molecule without melanogenic effects. It is researched for inflammatory bowel conditions, skin inflammation, and systemic anti-inflammatory applications.
Protocol Overview
- Compound
- KPV (Lys-Pro-Val — C-terminal fragment of alpha-MSH)
- Category
- Anti-Inflammatory Research Peptide / Gut Health
- Vial Size
- 5mg (5,000mcg)
- Reconstitution
- SubQ: 2mL bacteriostatic water → 2.5mg/mL. Oral: capsule form (no reconstitution)
- Route
- Oral (capsule) OR subcutaneous injection — route depends on target indication
- Frequency
- 1–2x daily (oral or SubQ)
Reconstitution Instructions
KPV can be used orally (capsule form, no reconstitution needed) or subcutaneously. For SubQ use: add 2mL bacteriostatic water to a 5mg vial for 2.5mg/mL. For gut/GI indications, oral is the preferred route. Always use sterile technique for injectable preparations.
Materials Needed (SubQ Route)
- 5mg KPV vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18–22 gauge for drawing)
- Insulin syringe (29–31 gauge) for SubQ injection
- Alcohol swabs and clean workspace
Reconstitution (SubQ) / Oral Use
- SubQ: Allow the KPV vial and bacteriostatic water to reach room temperature. Wipe rubber stoppers with an alcohol swab.
- Draw up exactly 2mL of bacteriostatic water. Inject slowly down the side of the vial. Final concentration: 2.5mg/mL (2,500mcg/mL).
- Gently swirl or roll. Do not shake. Solution should be clear. Store refrigerated.
- Oral: Take KPV capsules directly — no reconstitution required. Best absorbed on an empty stomach for systemic use, or with food for GI-targeted delivery.
Dosing Protocol
KPV dose and route depend on the target indication. Oral is preferred for GI/gut conditions; SubQ provides faster systemic absorption for systemic anti-inflammatory use.
| Route | Dose | Frequency | Indication | Cycle |
|---|---|---|---|---|
| Oral (capsule) | 500mcg–2mg | 1–2x daily | GI inflammation, IBD, gut health | 4–8 weeks |
| SubQ injection | 200–500mcg | 1–2x daily | Systemic anti-inflammatory, skin | 4–8 weeks |
Common protocol: 500mcg oral 2x daily for IBD/gut conditions. SubQ 200mcg 1–2x daily for systemic or skin inflammation. Vial lasts ~10–25 days SubQ at 200–500mcg/day.
Quick Dosing Reference (SubQ — at 2.5mg/mL, 5mg vial + 2mL BAC water)
| Units (Insulin Syringe) | Volume (mL) | Dose (mcg) | Dose (mg) |
|---|---|---|---|
| 8 | 0.08mL | 200mcg | 0.2mg |
| 12 | 0.12mL | 300mcg | 0.3mg |
| 20 | 0.2mL | 500mcg | 0.5mg |
| 40 | 0.4mL | 1,000mcg | 1mg |
| 80 | 0.8mL | 2,000mcg | 2mg |
Oral dosing: 500mcg–2mg per capsule, 1–2x daily. No unit calculation needed — capsule dose is as labeled.
Administration Guidelines
- Oral route: take capsule on an empty stomach for systemic absorption; with food to target gut/GI directly
- SubQ route: inject into lower abdomen or thigh using a 29–31 gauge insulin syringe
- Rotate SubQ injection sites with each administration
- Oral starting dose: 500mcg 1x daily; can increase to 2mg 2x daily as tolerated
- SubQ starting dose: 200mcg 1x daily; can increase to 500mcg 2x daily as tolerated
- Store reconstituted (SubQ) solution refrigerated at 36–46°F (2–8°C)
- Use reconstituted solution within 30 days; never freeze
- Cycle: 4–8 weeks on, assess response, repeat as needed
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) / Capsules | Room temperature or refrigerated, protect from light |
| Reconstituted (2.5mg/mL) | Refrigerated 36–46°F (2–8°C), use within 30 days |
Stacking Recommendations
Compatible Compounds
- BPC-157: Synergistic gut healing and tissue repair
- Thymosin Alpha-1: Immune modulation and anti-inflammatory support
- LL-37: Antimicrobial peptide with complementary anti-inflammatory activity
- Pentadecapeptide (PDA): Gut barrier and anti-inflammatory support
Popular Stacks
- Gut Health Stack: KPV 500mcg oral 2x/day + BPC-157 250mcg SubQ 1x/day
- Anti-Inflammatory: KPV 200mcg SubQ 2x/day + Thymosin Alpha-1 1.5mg SubQ 2x/week
- Wound/Skin: KPV 200mcg SubQ + LL-37 topical or SubQ