Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
GLP-1 Receptor Agonist
Weekly Protocol Guide
Liraglutide Protocol Guide
Liraglutide is a GLP-1 receptor agonist with 97% homology to native GLP-1. It is studied for weight management and metabolic research. It reduces appetite and caloric intake via central satiety pathways and delayed gastric emptying.
Protocol Overview
- Compound
- Liraglutide (Saxenda - Weight Loss Research Peptide)
- Category
- GLP-1 Receptor Agonist
- Vial Size
- 6mg (6,000mcg)
- Reconstitution
- 2mL bacteriostatic water (3mg/mL)
- Route
- Subcutaneous injection
- Frequency
- 7 days/week
Reconstitution Instructions
Using 2mL of bacteriostatic water results in a concentration of 3mg/mL. Start at 0.6mg and titrate up weekly. Always use sterile techniques.
Materials Needed
- 6mg Liraglutide 6mg vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18-22 gauge for drawing)
- Alcohol swabs
- Clean workspace
Step-by-Step Process
- Preparation: Allow the Liraglutide 6mg vial and bacteriostatic water to reach room temperature. Wipe the rubber stoppers of both vials with an alcohol swab.
- Draw the Water: Using a sterile syringe, draw up exactly 2mL of bacteriostatic water. Expel any air bubbles.
- Inject into Vial: Insert the needle through the rubber stopper at a slight angle, aiming toward the glass wall. Slowly inject the water down the side of the vial to avoid foaming.
- Mix Gently: Remove the needle. Gently swirl or roll the vial between your hands. Do not shake vigorously.
- Check for Clarity: The solution should be clear once fully reconstituted. Do not use if cloudy.
Weekly Dosing Schedule
| Day | Units | Dose | Timing |
|---|---|---|---|
| Monday | 20 | 0.6mg | Morning |
| Tuesday | 20 | 0.6mg | Morning |
| Wednesday | 20 | 0.6mg | Morning |
| Thursday | 20 | 0.6mg | Morning |
| Friday | 20 | 0.6mg | Morning |
| Saturday | 20 | 0.6mg | Morning |
| Sunday | 20 | 0.6mg | Morning |
Weekly Total: 140 units (4.2mg at starting dose) • Vial Duration: ~10 days at starting dose
Quick Dosing Reference
| Units (Ticks) | Dose (mcg) | Dose (mg) |
|---|---|---|
| 6.7 | 200 | 0.2mg |
| 10 | 300 | 0.3mg |
| 20 | 600 | 0.6mg |
| 40 | 1200 | 1.2mg |
| 60 | 1800 | 1.8mg |
| 80 | 2400 | 2.4mg |
| 100 | 3000 | 3.0mg |
Administration Guidelines
- Administer subcutaneously once daily at approximately the same time each day
- Start at 0.6mg daily for one week then titrate up by 0.6mg each week to target of 3.0mg
- Rotate injection sites between abdomen, thigh, and upper arm
- Common initial side effects include nausea - titrate slowly to minimize
- Store reconstituted peptide refrigerated at 36-46F (2-8C)
- Use reconstituted solution within 30 days
- Never freeze reconstituted peptides
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) | Room temperature or refrigerated, protect from light |
| Reconstituted | Refrigerated 36-46F (2-8C), use within 30 days |