Selank Protocol Guide
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory peptide tuftsin (threonyl-lysyl-prolyl-arginine). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank exhibits potent anxiolytic and nootropic effects without sedation or dependence. It modulates GABAergic, serotonergic, and dopaminergic neurotransmission, upregulates BDNF expression, and enhances IL-6 and enkephalin levels. This protocol covers intranasal dosing at 250-500mcg 2-3x daily, cycling strategies, and cognitive stacking.
Protocol Overview
- Compound
- Selank (TP-7)
- Category
- Anxiolytic Nootropic / Immunomodulator
- Mechanism
- Modulates GABA-A receptor allosteric sites, increases BDNF expression, enhances serotonin metabolism, stabilizes enkephalins, IL-6 modulation
- MW
- 751.9 Da (7 amino acids)
- Half-Life
- ~2-3 minutes (intranasal bioavailability extends effective duration to 3-6 hours)
- Form
- Nasal spray (0.15% solution) or lyophilized powder
- Route
- Intranasal (preferred) or subcutaneous
- Frequency
- 2-3x daily
- Cycle
- 2-4 weeks on / 2 weeks off
Dosing
| Protocol | Dose | Frequency | Notes |
|---|---|---|---|
| Standard Intranasal | 250 mcg per nostril (500 mcg total) | 2-3x daily | Morning, midday, optional afternoon |
| Low / Introductory | 150 mcg per nostril (300 mcg total) | 2x daily | First 3-5 days |
| Subcutaneous | 250-500 mcg | 1-2x daily | Alternative route if nasal not available |
For nasal spray: standard 0.15% solution delivers approximately 75mcg per spray. Use 2-3 sprays per nostril per dose. Clear nasal passages before administration. Effects typically felt within 5-15 minutes intranasally.
Timeline
Side Effects & Stacking
Side Effects
- Mild nasal irritation (intranasal route)
- Slight fatigue in first 1-2 days (rare)
- Very rare: mild headache
- No sedation, dependence, or withdrawal
- No cognitive impairment (unlike benzodiazepines)
Stacking
- Semax: Complementary nootropic synergy (classic Russian stack)
- NAD+: Neuroprotective + metabolic support
- GHK-Cu: Neuroregeneration + anti-aging
- BPC-157: Gut-brain axis + serotonergic support
- Dihexa: Advanced cognitive enhancement
Blood Work
| Panel | Markers | Timing |
|---|---|---|
| Immune | CBC w/ differential, IL-6, IgA/IgG/IgM | Baseline, Week 4 |
| Metabolic | CMP, thyroid panel | Baseline |
| Neurological | BDNF (if available), cortisol | Baseline, Week 4 |
