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GHRH AnalogEvidence Grade: A (FDA-Approved)
Sermorelin Protocol Guide
Sermorelin (GRF 1-29) is a 29-amino acid growth hormone releasing hormone (GHRH) analog and one of the earliest FDA-approved GH-stimulating peptides. It stimulates natural pulsatile GH release from the pituitary gland, making it a well-studied option for GH optimization research. This protocol covers reconstitution from a 10mg vial, subcutaneous dosing at 200-300mcg before bed, expected IGF-1 response, and combination protocols with GHRPs like ipamorelin.
Protocol Overview
- Compound
- Sermorelin (GRF 1-29)
- Category
- GHRH Analog
- Mechanism
- Binds GHRH receptors on pituitary somatotroph cells to stimulate natural pulsatile GH release
- MW
- 3,357.9 Da
- Half-Life
- ~10-20 minutes
- Vial
- 10mg lyophilized powder
- Route
- Subcutaneous
- Frequency
- 1x daily (before bed)
- Cycle
- 8-16 weeks
Dosing
| Protocol | Weeks | Dose | Frequency |
|---|---|---|---|
| Standard | 1-12 | 200-300 mcg | 1x daily before bed, fasted |
| With GHRP | 1-12 | 200mcg + 200mcg Ipamorelin | 2-3x daily, fasted |
Inject on empty stomach 30-60 min before sleep. Reconstitute 10mg with 2mL BAC water = 5mg/mL. 200mcg = 4 units.
Timeline
Week 1-2
Improved sleep quality. Initial GH pulse optimization.
Week 3-4
Enhanced recovery. Skin improvements. IGF-1 beginning to rise.
Week 5-8
Body composition changes. Fat loss and improved recovery. Measurable IGF-1 elevation.
Week 9-12
Peak effects. Lean mass, anti-aging skin, joint comfort. Consider 4-8 week break after cycle.
Side Effects
Common
- Injection site redness
- Mild water retention
- Flushing at injection site
- Headache initially
Stacking
- Ipamorelin: Synergistic GHRH+GHRP
- GHRP-2/6: Alternative GHRP pairing
- BPC-157: Recovery support
- GHK-Cu: Skin/collagen synergy
Blood Work
| Panel | Markers | Timing |
|---|---|---|
| GH Axis | IGF-1, GH | Baseline, Week 4, 8 |
| Metabolic | Fasting glucose, insulin | Baseline, Week 8 |
| Basic | CBC, CMP | Baseline, Week 8 |
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